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The Downstate Biotechnology Incubator, New York, home to Concarlo’s headquarters.

Concarlo Holdings LLC, has today announced that US Patent 10,702,570 was issued by the United States Patent and Trademark Office on July 07, 2020, marking the latest step in Concarlo’s journey to commercialize revolutionary medicines for metastatic breast cancer. The patent, for which Concarlo is the exclusive licensee, covers IpY, a novel therapeutic peptide that addresses drug-resistant breast cancer by targeting a unique cellular pathway — p27Kip1. Concarlo has also announced that a new provisional patent application has been filed for modified versions of the therapeutic peptide that are believed to exhibit enhanced bioavailability. Concarlo is a Brooklyn-based biotechnology innovator dedicated to developing sophisticated, targeted therapies and diagnostics in the oncology space. The IpY technology is the first to address the high incidence of drug-refractory disease that develops with currently available CDK4 inhibitor (CDK4i) treatments. Such a solution has the potential to drastically increase overall survival of breast cancer patients.

With more than 40,000 deaths due to metastatic breast cancer estimated for this year alone in the US, there is a pressing need to bring newer, more effective therapeutics to market. The recent introduction of CDK4i drugs, a class of medicines that directly targets the CDK4/6 pathway implicated in many malignancies, has had a significant impact on the way in which the disease is managed. However, such therapeutics are associated with patients transitioning to a treatment-resistant form of the condition, despite initial extended periods of remission. Backed by more than 20 years of research and development expertise, Concarlo has developed IpY and a companion diagnostic, ApY, to effectively overcome the issue of CDK4i resistance and roll out a more targeted treatment approach for optimized patient outcomes.

“Despite the clinical efficacy of CDK4 inhibitors, we’re seeing that primary or secondary resistance to therapy is presenting a significant challenge to overall survival,” commented Dr. Dominique Bridon, Chief Development Officer at Concarlo. “With the IpY technology and its unique mechanism of action, we’re effectively targeting CDK4 while simultaneously inhibiting another target — CDK2 — which has been found to be a key molecular player in the development of drug resistance. In doing so, we are the first company to successfully address the CDK4i resistance issue to provide long-term durable tumor arrest. Combined with its highly specific targeting and low toxicity profile, the positive impact of this drug on the breast cancer treatment landscape is hard to understate.”

Click on the image above to watch a video outlining Concarlo’s mission.

Concarlo was formed in 2016 and is supported by a team of internationally renowned experts forming its Scientific Advisory Board. To date, the company has raised more than $3.1 million to support the development, improvement, and commercialization of its IpY and ApY technologies to bring a precision medicine approach to breast cancer management. The newly issued patent for IpY and the provisional patent application for modified versions of the peptide are the first key milestones in Concarlo’s plan to build an extensive patent estate to maintain market exclusivity for its clinically relevant therapeutics.

“The issuance of this patent is a huge step, validating our focused efforts and activities to-date,” commented LisaMarie Casey, Co-founder and Chief Operating Officer of Concarlo. “The new U.S. patent and the pending provisional application perfectly position us to continue our innovative work with a technology that has the ability to overcome a significant challenge in breast cancer care — that of CDK4i resistance. We look forward to exploring opportunities for further partnerships and collaborations as we realize the commercialization of IpY.”

To find out more about Concarlo Holdings and its innovative IpY and ApY technology, please visit www.concarlo.com.

About Concarlo Holdings, LLC
Founded in 2016 and headquartered at the Downstate Biotechnology Incubator in Brooklyn, New York, Concarlo is a precision-medicine oncology company focused on diagnosing and treating cancer with an innovative approach to targeting a unique cellular pathway. The approach exploits the discovery that an alternate system (p27Kip1) controls the activity of CDK4/6 and CDK2 — critical proteins involved in the development of several cancers. Concarlo’s novel IpY therapeutic will be the first inhibitor to solve the CDK2 resistance issue, the first therapeutic to target p27 and the first to inhibit CDK4 and CDK2 simultaneously. More information about Concarlo can be found at: www.concarlo.com